LCMS使用液相色譜作為分離系統，質(zhì)譜作為檢測系統。 樣品在質(zhì)譜部分與流動(dòng)相分離。 離子碎片被電離后，由質(zhì)譜儀的質(zhì)量分析器根據荷質(zhì)比進(jìn)行分離，由檢測器得到質(zhì)譜圖。 LCMS可以分析GCMS無(wú)法分析的強極性、難揮發(fā)、熱不穩定的化合物，具有分析范圍廣、分析能力強、定性分析結果可靠、檢測限低等優(yōu)點(diǎn)。
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